- docente: TARITA BIVER
- docente: FRANCESCA MODUGNO
Learning outcomes
The student who successfully completes the course will have a working knowledge of the following topics and the capacity of planning and autonomously performing the related tasks in an Organic chemistry laboratory:
• inert-atmosphere operations;
• purification/drying or reagents and solvents;
• handling of sensitive substances (organometallics, hydrides) and evaluation of their titre;
• handling of chiral compounds and techniques for enantiomeric enrichment;
• main methods for determining the enantiomeric composition of chiral compounds.
Course contents
Standard Schlenk techniques and execution of main Organic chemistry lab operation under inert atmosphere. Handling of metal hydrides and organometallics and methods for evaluating their titre. Purification and drying of reagents and solvents.
Phase diagrams of mixtures of enantiomers and consequences for their correct handling and stereochemical enrichment. Main methods for the determination of enantiomeric composition, especially by gas-liquid and high-performance liquid chromatography.
In preparation to the laboratory practice, each working team will carry out a focused literature search. This will be aimed at planning suitable synthetic routes and analytical procedures for completing the experimental assignment.
Recommended or required reading
Recommended reading includes the following works:
B.S. Furniss et Al. «Vogel’s Textbook of Practical Organic Chemistry», 5th ed. (1989), Longman Scientific&Technical.
R.J. Errington «Advanced Practical Inorganic and Metalorganic Chemistry», (1997), Blackie Acad.&Prof.
J. Leonard et Al. «Advanced Practical Organic Chemistry», 2nd ed. (1998), Taylor&Francis-CRC.
A. Collet et Al. «Enantiomers, racemates and resolutions», (1981), J. Wiley&Sons
Houben-Weyl «Stereoselective Synthesis», ed. E21(1996), Vol. 1.
Assessment methods and criteria
The final mark obtained by each student will be calculated by adding-up the following four partial ratings (as 1/30):
1) Preparation work (literature search) 0-5 points
2) Laboratory attendance 0-10 points
3) Written report 0-10 points
4) Oral exam
The preparation work (team evaluation) will be assessed on the basis of the comprehensiveness of the literature search, its critical elaboration and (individual evaluation) the capacity of the team members to sustain their proposed solutions in the course of a short oral presentation.
The proficiency of the laboratory practice will be assessed individually, with particular regard to: care in performing the work, knowledge of the experimental plan and understanding of the performed operations. Unjustified nonattendance of the laboratory class sessions will be rated negatively.
The evaluation criteria of the written report (team evaluation) will include scientific and formal correctness, clarity, and comprehensiveness of each of the report’ sections (Introduction, Results and Discussion, Experimental).
During the oral exam (individual evaluation) the student must be able to demonstrate his/her knowledge of the course material and the ability to devise an experimental plan for solving problems related to the course topics.
The student who successfully completes the course will have a working knowledge of the following topics and the capacity of planning and autonomously performing the related tasks in an Organic chemistry laboratory:
• inert-atmosphere operations;
• purification/drying or reagents and solvents;
• handling of sensitive substances (organometallics, hydrides) and evaluation of their titre;
• handling of chiral compounds and techniques for enantiomeric enrichment;
• main methods for determining the enantiomeric composition of chiral compounds.
Course contents
Standard Schlenk techniques and execution of main Organic chemistry lab operation under inert atmosphere. Handling of metal hydrides and organometallics and methods for evaluating their titre. Purification and drying of reagents and solvents.
Phase diagrams of mixtures of enantiomers and consequences for their correct handling and stereochemical enrichment. Main methods for the determination of enantiomeric composition, especially by gas-liquid and high-performance liquid chromatography.
In preparation to the laboratory practice, each working team will carry out a focused literature search. This will be aimed at planning suitable synthetic routes and analytical procedures for completing the experimental assignment.
Recommended or required reading
Recommended reading includes the following works:
B.S. Furniss et Al. «Vogel’s Textbook of Practical Organic Chemistry», 5th ed. (1989), Longman Scientific&Technical.
R.J. Errington «Advanced Practical Inorganic and Metalorganic Chemistry», (1997), Blackie Acad.&Prof.
J. Leonard et Al. «Advanced Practical Organic Chemistry», 2nd ed. (1998), Taylor&Francis-CRC.
A. Collet et Al. «Enantiomers, racemates and resolutions», (1981), J. Wiley&Sons
Houben-Weyl «Stereoselective Synthesis», ed. E21(1996), Vol. 1.
Assessment methods and criteria
The final mark obtained by each student will be calculated by adding-up the following four partial ratings (as 1/30):
1) Preparation work (literature search) 0-5 points
2) Laboratory attendance 0-10 points
3) Written report 0-10 points
4) Oral exam
The preparation work (team evaluation) will be assessed on the basis of the comprehensiveness of the literature search, its critical elaboration and (individual evaluation) the capacity of the team members to sustain their proposed solutions in the course of a short oral presentation.
The proficiency of the laboratory practice will be assessed individually, with particular regard to: care in performing the work, knowledge of the experimental plan and understanding of the performed operations. Unjustified nonattendance of the laboratory class sessions will be rated negatively.
The evaluation criteria of the written report (team evaluation) will include scientific and formal correctness, clarity, and comprehensiveness of each of the report’ sections (Introduction, Results and Discussion, Experimental).
During the oral exam (individual evaluation) the student must be able to demonstrate his/her knowledge of the course material and the ability to devise an experimental plan for solving problems related to the course topics.
- docente: ALESSANDRO MANDOLI